Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study
Identifieur interne : 000C17 ( Main/Corpus ); précédent : 000C16; suivant : 000C18Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study
Auteurs : Adolfo Mínguez-Castellanos ; Francisco Escamilla-Sevilla ; Gary R. Hotton ; Juan J. Toledo-Aral ; Ángel Ortega-Moreno ; Sim N Méndez-Ferrer ; José M. Martín-Linares ; Majed J. Katati ; Pablo Mir ; Javier Villadiego ; Miguel Meersmans ; Miguel Pérez-García ; David J. Brooks ; Ventura Arjona ; José L Pez-BarneoSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2007-08.
English descriptors
- KwdEn :
- CAPIT, Core Assessment Programme for Intracerebral Transplantation, CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease, CB, carotid body, GDNF, glial cell line derived neurotrophic factor, PD, Parkinson disease, PET, positron emission tomography, TH, tyrosine hydroxylase, UPDRS, Unified Parkinson’s Disease Rating Scale.
Abstract
Background: Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD). Objective: We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD. Methods: Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had 18F-dopa positron emission tomography scans before and 1 year after transplantation. Results: Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal 18F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal 18F-dopa uptake (r = −0.829; p = 0.042). Conclusions: CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.
Url:
DOI: 10.1136/jnnp.2006.106021
Links to Exploration step
ISTEX:B3A39B161A1B7B7E5CFF67D04FBF430965A48510Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title><author><name sortKey="Minguez Castellanos, Adolfo" sort="Minguez Castellanos, Adolfo" uniqKey="Minguez Castellanos A" first="Adolfo" last="Mínguez-Castellanos">Adolfo Mínguez-Castellanos</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Escamilla Sevilla, Francisco" sort="Escamilla Sevilla, Francisco" uniqKey="Escamilla Sevilla F" first="Francisco" last="Escamilla-Sevilla">Francisco Escamilla-Sevilla</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Hotton, Gary R" sort="Hotton, Gary R" uniqKey="Hotton G" first="Gary R" last="Hotton">Gary R. Hotton</name><affiliation><mods:affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</mods:affiliation></affiliation></author><author><name sortKey="Toledo Aral, Juan J" sort="Toledo Aral, Juan J" uniqKey="Toledo Aral J" first="Juan J" last="Toledo-Aral">Juan J. Toledo-Aral</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Ortega Moreno, Angel" sort="Ortega Moreno, Angel" uniqKey="Ortega Moreno A" first="Ángel" last="Ortega-Moreno">Ángel Ortega-Moreno</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mendez Ferrer, Sim N" sort="Mendez Ferrer, Sim N" uniqKey="Mendez Ferrer S" first="Sim N" last="Méndez-Ferrer">Sim N Méndez-Ferrer</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Martin Linares, Jose M" sort="Martin Linares, Jose M" uniqKey="Martin Linares J" first="José M" last="Martín-Linares">José M. Martín-Linares</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Katati, Majed J" sort="Katati, Majed J" uniqKey="Katati M" first="Majed J" last="Katati">Majed J. Katati</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Villadiego, Javier" sort="Villadiego, Javier" uniqKey="Villadiego J" first="Javier" last="Villadiego">Javier Villadiego</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Meersmans, Miguel" sort="Meersmans, Miguel" uniqKey="Meersmans M" first="Miguel" last="Meersmans">Miguel Meersmans</name><affiliation><mods:affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Perez Garcia, Miguel" sort="Perez Garcia, Miguel" uniqKey="Perez Garcia M" first="Miguel" last="Pérez-García">Miguel Pérez-García</name><affiliation><mods:affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name><affiliation><mods:affiliation>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Arjona, Ventura" sort="Arjona, Ventura" uniqKey="Arjona V" first="Ventura" last="Arjona">Ventura Arjona</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="L Pez Barneo, Jose" sort="L Pez Barneo, Jose" uniqKey="L Pez Barneo J" first="José" last="L Pez-Barneo">José L Pez-Barneo</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B3A39B161A1B7B7E5CFF67D04FBF430965A48510</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1136/jnnp.2006.106021</idno><idno type="url">https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title><author><name sortKey="Minguez Castellanos, Adolfo" sort="Minguez Castellanos, Adolfo" uniqKey="Minguez Castellanos A" first="Adolfo" last="Mínguez-Castellanos">Adolfo Mínguez-Castellanos</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Escamilla Sevilla, Francisco" sort="Escamilla Sevilla, Francisco" uniqKey="Escamilla Sevilla F" first="Francisco" last="Escamilla-Sevilla">Francisco Escamilla-Sevilla</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Hotton, Gary R" sort="Hotton, Gary R" uniqKey="Hotton G" first="Gary R" last="Hotton">Gary R. Hotton</name><affiliation><mods:affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</mods:affiliation></affiliation></author><author><name sortKey="Toledo Aral, Juan J" sort="Toledo Aral, Juan J" uniqKey="Toledo Aral J" first="Juan J" last="Toledo-Aral">Juan J. Toledo-Aral</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Ortega Moreno, Angel" sort="Ortega Moreno, Angel" uniqKey="Ortega Moreno A" first="Ángel" last="Ortega-Moreno">Ángel Ortega-Moreno</name><affiliation><mods:affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mendez Ferrer, Sim N" sort="Mendez Ferrer, Sim N" uniqKey="Mendez Ferrer S" first="Sim N" last="Méndez-Ferrer">Sim N Méndez-Ferrer</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Martin Linares, Jose M" sort="Martin Linares, Jose M" uniqKey="Martin Linares J" first="José M" last="Martín-Linares">José M. Martín-Linares</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Katati, Majed J" sort="Katati, Majed J" uniqKey="Katati M" first="Majed J" last="Katati">Majed J. Katati</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Villadiego, Javier" sort="Villadiego, Javier" uniqKey="Villadiego J" first="Javier" last="Villadiego">Javier Villadiego</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author><author><name sortKey="Meersmans, Miguel" sort="Meersmans, Miguel" uniqKey="Meersmans M" first="Miguel" last="Meersmans">Miguel Meersmans</name><affiliation><mods:affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Perez Garcia, Miguel" sort="Perez Garcia, Miguel" uniqKey="Perez Garcia M" first="Miguel" last="Pérez-García">Miguel Pérez-García</name><affiliation><mods:affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name><affiliation><mods:affiliation>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Arjona, Ventura" sort="Arjona, Ventura" uniqKey="Arjona V" first="Ventura" last="Arjona">Ventura Arjona</name><affiliation><mods:affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</mods:affiliation></affiliation></author><author><name sortKey="L Pez Barneo, Jose" sort="L Pez Barneo, Jose" uniqKey="L Pez Barneo J" first="José" last="L Pez-Barneo">José L Pez-Barneo</name><affiliation><mods:affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2007-08">2007-08</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="825">825</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">B3A39B161A1B7B7E5CFF67D04FBF430965A48510</idno><idno type="DOI">10.1136/jnnp.2006.106021</idno><idno type="href">jnnp-78-825.pdf</idno><idno type="PMID">17220289</idno><idno type="local">0780825</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CAPIT, Core Assessment Programme for Intracerebral Transplantation</term><term>CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease</term><term>CB, carotid body</term><term>GDNF, glial cell line derived neurotrophic factor</term><term>PD, Parkinson disease</term><term>PET, positron emission tomography</term><term>TH, tyrosine hydroxylase</term><term>UPDRS, Unified Parkinson’s Disease Rating Scale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD). Objective: We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD. Methods: Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had 18F-dopa positron emission tomography scans before and 1 year after transplantation. Results: Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal 18F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal 18F-dopa uptake (r = −0.829; p = 0.042). Conclusions: CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Adolfo Mínguez-Castellanos</name><affiliations><json:string>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Francisco Escamilla-Sevilla</name><affiliations><json:string>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Gary R Hotton</name><affiliations><json:string>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</json:string></affiliations></json:item><json:item><name>Juan J Toledo-Aral</name><affiliations><json:string>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</json:string></affiliations></json:item><json:item><name>Ángel Ortega-Moreno</name><affiliations><json:string>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Simón Méndez-Ferrer</name><affiliations><json:string>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</json:string></affiliations></json:item><json:item><name>José M Martín-Linares</name><affiliations><json:string>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Majed J Katati</name><affiliations><json:string>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Pablo Mir</name><affiliations><json:string>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</json:string></affiliations></json:item><json:item><name>Javier Villadiego</name><affiliations><json:string>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</json:string></affiliations></json:item><json:item><name>Miguel Meersmans</name><affiliations><json:string>Facultad de Psicología, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>Miguel Pérez-García</name><affiliations><json:string>Facultad de Psicología, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>David J Brooks</name><affiliations><json:string>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</json:string></affiliations></json:item><json:item><name>Ventura Arjona</name><affiliations><json:string>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>José López-Barneo</name><affiliations><json:string>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Papers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Drugs: CNS (not psychiatric)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radiology (diagnostics)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CAPIT, Core Assessment Programme for Intracerebral Transplantation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CB, carotid body</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GDNF, glial cell line derived neurotrophic factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PD, Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PET, positron emission tomography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TH, tyrosine hydroxylase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>UPDRS, Unified Parkinson’s Disease Rating Scale</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background: Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD). Objective: We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD. Methods: Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had 18F-dopa positron emission tomography scans before and 1 year after transplantation. Results: Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal 18F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal 18F-dopa uptake (r = −0.829; p = 0.042). Conclusions: CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.</abstract><qualityIndicators><score>8</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>13</keywordCount><abstractCharCount>1986</abstractCharCount><pdfWordCount>5413</pdfWordCount><pdfCharCount>37421</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>279</abstractWordCount></qualityIndicators><title>Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title><pmid><json:string>17220289</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>78</volume><pages><first>825</first></pages><issn><json:string>0022-3050</json:string></issn><issue>8</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1136/jnnp.2006.106021</json:string></doi><id>B3A39B161A1B7B7E5CFF67D04FBF430965A48510</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2007-01-12</date></publicationStmt><notesStmt><note>Correspondence to:
Dr José López-Barneo
Laboratorio de Investigaciones Biomédicas, Edificio de Laboratorios, 2a planta, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot, s/n. 41013 Seville, Spain; Jose.l.Barneo.sspa@juntadeandalucia.es</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title><author><persName><forename type="first">Adolfo</forename><surname>Mínguez-Castellanos</surname></persName><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Francisco</forename><surname>Escamilla-Sevilla</surname></persName><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Gary R</forename><surname>Hotton</surname></persName><affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</affiliation></author><author><persName><forename type="first">Juan J</forename><surname>Toledo-Aral</surname></persName><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation></author><author><persName><forename type="first">Ángel</forename><surname>Ortega-Moreno</surname></persName><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Simón</forename><surname>Méndez-Ferrer</surname></persName><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation></author><author><persName><forename type="first">José M</forename><surname>Martín-Linares</surname></persName><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Majed J</forename><surname>Katati</surname></persName><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Pablo</forename><surname>Mir</surname></persName><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation></author><author><persName><forename type="first">Javier</forename><surname>Villadiego</surname></persName><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation></author><author><persName><forename type="first">Miguel</forename><surname>Meersmans</surname></persName><affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">Miguel</forename><surname>Pérez-García</surname></persName><affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">David J</forename><surname>Brooks</surname></persName><affiliation>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</affiliation></author><author><persName><forename type="first">Ventura</forename><surname>Arjona</surname></persName><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation></author><author><persName><forename type="first">José</forename><surname>López-Barneo</surname></persName><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2007-08"></date><biblScope unit="volume">78</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="825">825</biblScope></imprint></monogr><idno type="istex">B3A39B161A1B7B7E5CFF67D04FBF430965A48510</idno><idno type="DOI">10.1136/jnnp.2006.106021</idno><idno type="href">jnnp-78-825.pdf</idno><idno type="PMID">17220289</idno><idno type="local">0780825</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007-01-12</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD). Objective: We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD. Methods: Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had 18F-dopa positron emission tomography scans before and 1 year after transplantation. Results: Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal 18F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal 18F-dopa uptake (r = −0.829; p = 0.042). Conclusions: CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.</p></abstract><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Drugs: CNS (not psychiatric)</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Parkinson's disease</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Radiology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Radiology (diagnostics)</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>CAPIT, Core Assessment Programme for Intracerebral Transplantation</term></item><item><term>CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease</term></item><item><term>CB, carotid body</term></item><item><term>GDNF, glial cell line derived neurotrophic factor</term></item><item><term>PD, Parkinson disease</term></item><item><term>PET, positron emission tomography</term></item><item><term>TH, tyrosine hydroxylase</term></item><item><term>UPDRS, Unified Parkinson’s Disease Rating Scale</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-01-12">Created</change><change when="2007-08">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">0780825</article-id><article-id pub-id-type="doi">10.1136/jnnp.2006.106021</article-id><article-id pub-id-type="other">jnnp;78/8/825</article-id><article-id pub-id-type="other">jnnp;jnnp.2006.106021</article-id><article-id pub-id-type="pmid">17220289</article-id><article-id pub-id-type="other">825</article-id><article-id pub-id-type="other">jnnp.2006.106021</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Papers</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Drugs: CNS (not psychiatric)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Parkinson's disease</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology (diagnostics)</subject></subj-group></article-categories><title-group><article-title>Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Mínguez-Castellanos</surname><given-names>Adolfo</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Escamilla-Sevilla</surname><given-names>Francisco</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hotton</surname><given-names>Gary R</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Toledo-Aral</surname><given-names>Juan J</given-names></name><xref rid="AFF4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ortega-Moreno</surname><given-names>Ángel</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Méndez-Ferrer</surname><given-names>Simón</given-names></name><xref rid="AFF4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Martín-Linares</surname><given-names>José M</given-names></name><xref rid="AFF5">5</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Katati</surname><given-names>Majed J</given-names></name><xref rid="AFF5">5</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Mir</surname><given-names>Pablo</given-names></name><xref rid="AFF4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Villadiego</surname><given-names>Javier</given-names></name><xref rid="AFF4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Meersmans</surname><given-names>Miguel</given-names></name><xref rid="AFF6">6</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Pérez-García</surname><given-names>Miguel</given-names></name><xref rid="AFF6">6</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Brooks</surname><given-names>David J</given-names></name><xref rid="AFF3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Arjona</surname><given-names>Ventura</given-names></name><xref rid="AFF5">5</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>López-Barneo</surname><given-names>José</given-names></name><xref rid="AFF4">4</xref></contrib><aff id="AFF1"><label>1</label>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</aff><aff id="AFF2"><label>2</label>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</aff><aff id="AFF3"><label>3</label>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</aff><aff id="AFF4"><label>4</label>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</aff><aff id="AFF5"><label>5</label>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</aff><aff id="AFF6"><label>6</label>Facultad de Psicología, Universidad de Granada, Granada, Spain</aff></contrib-group><author-notes><corresp>Correspondence to:
Dr José López-Barneo
Laboratorio de Investigaciones Biomédicas, Edificio de Laboratorios, 2a planta, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot, s/n. 41013 Seville, Spain; <ext-link xlink:href="Jose.l.Barneo.sspa@juntadeandalucia.es" ext-link-type="email" xlink:type="simple">Jose.l.Barneo.sspa@juntadeandalucia.es</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>12</day><month>1</month><year>2007</year></pub-date><volume>78</volume><volume-id pub-id-type="other">78</volume-id><volume-id pub-id-type="other">78</volume-id><issue>8</issue><issue-id pub-id-type="other">jnnp;78/8</issue-id><issue-id pub-id-type="other">8</issue-id><issue-id pub-id-type="other">78/8</issue-id><fpage>825</fpage><history><date date-type="accepted"><day>26</day><month>12</month><year>2006</year></date><date date-type="received"><day>03</day><month>09</month><year>2006</year></date><date date-type="rev-recd"><day>16</day><month>11</month><year>2006</year></date></history><permissions><copyright-statement>Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</copyright-statement><copyright-year>2007</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-78-825.pdf"></self-uri><abstract xml:lang="en"><p><bold>Background:</bold> Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD).</p><p><bold>Objective:</bold> We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD.</p><p><bold>Methods:</bold> Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had <sup>18</sup>F-dopa positron emission tomography scans before and 1 year after transplantation.</p><p><bold>Results:</bold> Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal <sup>18</sup>F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal <sup>18</sup>F-dopa uptake (r = −0.829; p = 0.042).</p><p><bold>Conclusions:</bold> CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.</p></abstract><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>CAPIT, Core Assessment Programme for Intracerebral Transplantation</kwd><kwd>CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease</kwd><kwd>CB, carotid body</kwd><kwd>GDNF, glial cell line derived neurotrophic factor</kwd><kwd>PD, Parkinson disease</kwd><kwd>PET, positron emission tomography</kwd><kwd>TH, tyrosine hydroxylase</kwd><kwd>UPDRS, Unified Parkinson’s Disease Rating Scale</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study</title></titleInfo><name type="personal"><namePart type="given">Adolfo</namePart><namePart type="family">Mínguez-Castellanos</namePart><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francisco</namePart><namePart type="family">Escamilla-Sevilla</namePart><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gary R</namePart><namePart type="family">Hotton</namePart><affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Imperial College London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juan J</namePart><namePart type="family">Toledo-Aral</namePart><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ángel</namePart><namePart type="family">Ortega-Moreno</namePart><affiliation>Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simón</namePart><namePart type="family">Méndez-Ferrer</namePart><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José M</namePart><namePart type="family">Martín-Linares</namePart><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Majed J</namePart><namePart type="family">Katati</namePart><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pablo</namePart><namePart type="family">Mir</namePart><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Javier</namePart><namePart type="family">Villadiego</namePart><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel</namePart><namePart type="family">Meersmans</namePart><affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel</namePart><namePart type="family">Pérez-García</namePart><affiliation>Facultad de Psicología, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David J</namePart><namePart type="family">Brooks</namePart><affiliation>Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ventura</namePart><namePart type="family">Arjona</namePart><affiliation>Servicio de Neurocirugía, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José</namePart><namePart type="family">López-Barneo</namePart><affiliation>Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><genre>hwp-journal-coll</genre><topic>Drugs: CNS (not psychiatric)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Parkinson's disease</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology (diagnostics)</topic></subject><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2007-08</dateIssued><dateCreated encoding="w3cdtf">2007-01-12</dateCreated><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Background: Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD). Objective: We conducted a phase I–II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD. Methods: Thirteen patients with advanced PD underwent bilateral stereotactic implantation of CB cell aggregates into the striatum. They were assessed before surgery and up to 1–3 years after surgery according to CAPIT (Core Assessment Programme for Intracerebral Transplantation) and CAPSIT-PD (Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease) protocols. The primary outcome measure was the change in video blinded Unified Parkinson’s Disease Rating Scale III score in the off-medication state. Seven patients had 18F-dopa positron emission tomography scans before and 1 year after transplantation. Results: Clinical amelioration in the primary outcome measure was observed in 10 of 12 blindly analysed patients, which was maximal at 6–12 months after transplantation (5–74%). Overall, mean improvement at 6 months was 23%. In the long term (3 years), 3 of 6 patients still maintained improvement (15–48%). None of the patients developed off-period dyskinesias. The main predictive factors for motor improvement were the histological integrity of the CB and a milder disease severity. We observed a non-significant 5% increase in mean putaminal 18F-dopa uptake but there was an inverse relationship between clinical amelioration and annual decline in putaminal 18F-dopa uptake (r = −0.829; p = 0.042). Conclusions: CB autotransplantation may induce clinical effects in patients with advanced PD which seem partly related to the biological properties of the implanted glomus cells.</abstract><note type="author-notes">Correspondence to:
Dr José López-Barneo
Laboratorio de Investigaciones Biomédicas, Edificio de Laboratorios, 2a planta, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot, s/n. 41013 Seville, Spain; Jose.l.Barneo.sspa@juntadeandalucia.es</note><subject lang="en"><genre>ABR</genre><topic>CAPIT, Core Assessment Programme for Intracerebral Transplantation</topic><topic>CAPSIT-PD, Core Assessment Programme for Surgical Interventional Therapies in Parkinson’s Disease</topic><topic>CB, carotid body</topic><topic>GDNF, glial cell line derived neurotrophic factor</topic><topic>PD, Parkinson disease</topic><topic>PET, positron emission tomography</topic><topic>TH, tyrosine hydroxylase</topic><topic>UPDRS, Unified Parkinson’s Disease Rating Scale</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>825</start></extent></part></relatedItem><identifier type="istex">B3A39B161A1B7B7E5CFF67D04FBF430965A48510</identifier><identifier type="DOI">10.1136/jnnp.2006.106021</identifier><identifier type="href">jnnp-78-825.pdf</identifier><identifier type="PMID">17220289</identifier><identifier type="local">0780825</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/B3A39B161A1B7B7E5CFF67D04FBF430965A48510/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C17 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C17 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:B3A39B161A1B7B7E5CFF67D04FBF430965A48510
|texte= Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study
}}
| This area was generated with Dilib version V0.6.23. |  |